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Targeted Allele Detail
Symbol: Sirt1tm1.2Cxd
Name: sirtuin 1; targeted mutation 1.2, Chu-Xia Deng
MGI ID: MGI:5305225
Synonyms: Sirt1flox5-6
Gene: Sirt1  Location: Chr10:63319005-63381704 bp, - strand  Genetic Position: Chr10, 32.57 cM
Germline Transmission:  Earliest citation of germline transmission: J:179193
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsGerm line, cre mediated recombination was used to remove the neo cassette leaving exons 5 and 6 flanked by loxP sites. Liver specific deletion of the two floxed exons eliminates protein product in the liver. (J:140089, J:179193)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt1 Mutation:  46 strains or lines available
Original:  J:179193 Wang RH, et al., Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci. 2010;6(7):682-90
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory