About   Help   FAQ
Sirt1tm1.2Cxd
Targeted Allele Detail
Nomenclature
Symbol: Sirt1tm1.2Cxd
Name: sirtuin 1; targeted mutation 1.2, Chu-Xia Deng
MGI ID: MGI:5305225
Synonyms: Sirt1flox5-6
Gene: Sirt1  Location: Chr10:63319005-63381704 bp, - strand  Genetic Position: Chr10, 32.57 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179193
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation details
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt1 Mutation:  45 strains or lines available
References
Original:  J:179193 Wang RH, et al., Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition. Int J Biol Sci. 2010;6(7):682-90
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory