Myh11^tm1.1Rng
Targeted Allele Detail

Summary

• Symbol: Myh11^tm1.1Rng
• Name: myosin, heavy polypeptide 11, smooth muscle; targeted mutation 1.1, Ryozo Nagai
• MGI ID: MGI:5305173
• Gene: Myh11 Location: Chr16:14012392-14109227 bp, - strand Genetic Position: Chr16, 9.71 cM
• Alliance: Myh11^tm1.1Rng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179478
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: Exon 2, containing the transcription start codon was replaced by lacZ and a floxed neomycin and Tk selection cassette. The selection cassette was subsequently excised from properly targeted ES cells. (J:179478)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myh11 Mutation: 93 strains or lines available

References

• Original: J:179478 Iwata H, et al., Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages. Circulation. 2010 Nov 16;122(20):2048-57
• All: 1 reference(s)