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Notch3tm1.1(cre/ERT2)Sat
Targeted Allele Detail
Nomenclature
Symbol: Notch3tm1.1(cre/ERT2)Sat
Name: notch 3; targeted mutation 1.1, Spyros Artavanis-Tsakonas
MGI ID: MGI:5304914
Synonyms: N3-CreERT2SAT
Gene: Notch3  Location: Chr17:32339794-32385826 bp, - strand  Genetic Position: Chr17, 17.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179632
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was constructed to insert the cre/ERT2 coding sequence, a polyadenylation signal and an Frt-flanked neo selection cassette in-frame with the start codon of Notch 3, by homologous recombination in ES cells. This resulted in deletion of most of exon 1. Chimeric males were bred to Flpe-expressing females to remove the selection cassette. (J:179632)
Generation of the various Notch knock-in mice
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Notch3     Summary of all recombinase alleles driven by Notch3.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch3 Mutation:  61 strains or lines available
References
Original:  J:179632 Fre S, et al., Notch lineages and activity in intestinal stem cells determined by a new set of knock-in mice. PLoS One. 2011;6(10):e25785
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/03/2022
MGI 6.19
The Jackson Laboratory