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Igh-Jtm1(CB20)Riho
Targeted Allele Detail
Nomenclature
Symbol: Igh-Jtm1(CB20)Riho
Name: immunoglobulin heavy chain, joining region; targeted mutation 1, Rikard Holmdahl
MGI ID: MGI:5304723
Synonyms: ABC-
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179456
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe Igh-J region was replaced with a prearranged VDJ segment CB20 (a germline-encoded anti-C1 antibody). A floxed neo cassette was removed by cre-mediated recombination. (J:179456)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
References
Original:  J:179456 Cao D, et al., Pathogenic autoreactive B cells are not negatively selected toward matrix protein collagen II. J Immunol. 2011 Nov 1;187(9):4451-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory