Thra^tm1.1Fcas
Targeted Allele Detail

Summary

• Symbol: Thra^tm1.1Fcas
• Name: thyroid hormone receptor alpha; targeted mutation 1.1, Francois Casas
• MGI ID: MGI:5304668
• Synonyms: p43^-
• Gene: Thra Location: Chr11:98631539-98659832 bp, + strand Genetic Position: Chr11, 62.58 cM, cytoband D-E
• Alliance: Thra^tm1.1Fcas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:179839
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 3 was replaced with one in which a nucleotide substitution produced the amino acid substitution of leucine for methionine at position 109 (M109L). The floxed neo cassette inserted downstream of exon 4 was removed by cre-mediated recombination. Western blot analysis on quadriceps muscle extracts confirmed the absence of protein expression. (J:179839)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thra Mutation: 39 strains or lines available

References

• Original: J:179839 Blanchet E, et al., Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis. FASEB J. 2012 Jan;26(1):40-50
• All: 8 reference(s)