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Thratm1.1Fcas
Targeted Allele Detail
Nomenclature
Symbol: Thratm1.1Fcas
Name: thyroid hormone receptor alpha; targeted mutation 1.1, Francois Casas
MGI ID: MGI:5304668
Synonyms: p43-
Gene: Thra  Location: Chr11:98740638-98769006 bp, + strand  Genetic Position: Chr11, 62.58 cM, cytoband D-E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179839
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Single point mutation
 
Mutation detailsExon 3 was replaced with one in which a nucleotide substitution produced the amino acid substitution of leucine for methionine at position 109 (M109L). The floxed neo cassette inserted downstream of exon 4 was removed by cre-mediated recombination. Western blot analysis on quadriceps muscle extracts confirmed the absence of protein expression. (J:179839)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thra Mutation:  22 strains or lines available
References
Original:  J:179839 Blanchet E, et al., Mitochondrial T3 receptor p43 regulates insulin secretion and glucose homeostasis. FASEB J. 2012 Jan;26(1):40-50
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory