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Mecp2tm1.1Meg
Targeted Allele Detail
Summary
Symbol: Mecp2tm1.1Meg
Name: methyl CpG binding protein 2; targeted mutation 1.1, Michael E Greenberg
MGI ID: MGI:5302542
Synonyms: MeCP2 S421A
Gene: Mecp2  Location: ChrX:73070198-73129296 bp, - strand  Genetic Position: ChrX, 37.63 cM
Alliance: Mecp2tm1.1Meg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178533
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted upstream of a modified exon in which nucleotide substitution (A to C) results in the amino acid substitution of alanine for serine at position 421 (S421A). Cre-mediated recombination removed the neo cassette. (J:178533)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mecp2 Mutation:  38 strains or lines available
References
Original:  J:178533 Cohen S, et al., Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. Neuron. 2011 Oct 6;72(1):72-85
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory