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Targeted Allele Detail
Symbol: Pclaftm1.1Lkd
Name: PCNA clamp associated factor; targeted mutation 1.1, Lisa K Denzin
MGI ID: MGI:5302414
Synonyms: Paf-
Gene: Pclaf  Location: Chr9:65890237-65903266 bp, + strand  Genetic Position: Chr9, 35.58 cM
Germline Transmission:  Earliest citation of germline transmission: J:177782
Parent Cell Line:  CY2.4 (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of the translation initiation site in exon 1. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette, 3' portion of exon 1 downstream of the translation initiation codon, intron 1, and exon 2. Western blot analysis confirmed the absence of protein expression in thymocytes. (J:177782)
Generation of the Pclaftm1.1Lkd allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pclaf Mutation:  3 strains or lines available
Original:  J:177782 Amrani YM, et al., The Paf oncogene is essential for hematopoietic stem cell function and development. J Exp Med. 2011 Aug 29;208(9):1757-65
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory