Coro1b^tm1.1Nfoe
Targeted Allele Detail

Summary

• Symbol: Coro1b^tm1.1Nfoe
• Name: coronin, actin binding protein 1B; targeted mutation 1.1, Niko Foeger
• MGI ID: MGI:5302401
• Gene: Coro1b Location: Chr19:4198618-4204034 bp, + strand Genetic Position: Chr19, 3.85 cM
• Alliance: Coro1b^tm1.1Nfoe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177785
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 8. Cre-mediated recombination removed the neo cassette and exons 3 through 8. FACS analysis confirmed the absence of protein expression in bone marrow-derived mast cells. (J:177785)

Generation of the Coro1b^tm1.1Nfoe allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Coro1b Mutation: 30 strains or lines available

References

• Original: J:177785 Foger N, et al., Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. J Exp Med. 2011 Aug 29;208(9):1777-87
• All: 1 reference(s)