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Targeted Allele Detail
Symbol: Coro1btm1.1Nfoe
Name: coronin, actin binding protein 1B; targeted mutation 1.1, Niko Foeger
MGI ID: MGI:5302401
Gene: Coro1b  Location: Chr19:4148619-4154035 bp, + strand  Genetic Position: Chr19, 3.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:177785
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 3. A floxed neo cassette was inserted downstream of exon 8. Cre-mediated recombination removed the neo cassette and exons 3 through 8. FACS analysis confirmed the absence of protein expression in bone marrow-derived mast cells. (J:177785)
Generation of the Coro1btm1.1Nfoe allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Coro1b Mutation:  20 strains or lines available
Original:  J:177785 Foger N, et al., Differential regulation of mast cell degranulation versus cytokine secretion by the actin regulatory proteins Coronin1a and Coronin1b. J Exp Med. 2011 Aug 29;208(9):1777-87
All:  1 reference(s)

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MGI 6.11
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