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Targeted Allele Detail
Symbol: Mc3rtm1Butl
Name: melanocortin 3 receptor; targeted mutation 1, Andrew A Butler
MGI ID: MGI:5302394
Synonyms: Mc3rTB
Gene: Mc3r  Location: Chr2:172248492-172251114 bp, + strand  Genetic Position: Chr2, 94.8 cM
Germline Transmission:  Earliest citation of germline transmission: J:178147
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP-stop-loxP cassette was inserted just upstream of the initiation codon and an IRES-AcGFP1was inserted after the open reading frame via homologous recombination. (J:178147)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mc3r Mutation:  23 strains or lines available
Original:  J:178147 Begriche K, et al., Genetic Dissection of the Functions of the Melanocortin-3 Receptor, a Seven-transmembrane G-protein-coupled Receptor, Suggests Roles for Central and Peripheral Receptors in Energy Homeostasis. J Biol Chem. 2011 Nov 25;286(47):40771-81
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory