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Targeted Allele Detail
Symbol: Crbntm1.1Jjh
Name: cereblon; targeted mutation 1.1, Joseph Higgins
MGI ID: MGI:5302187
Gene: Crbn  Location: Chr6:106780201-106800077 bp, - strand  Genetic Position: Chr6, 49.24 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:179427
Parent Cell Line:  CY2.4 (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting vector containing a FRT site flanked PGK-Neo selection cassette and a loxP site was utilized in the construction of this mutant. This selection cassette was inserted 227 bp upstream of exon 3 of the targeted gene, and another loxP site was inserted 225 bp downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 3 and 4 floxed. (J:179427)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crbn Mutation:  22 strains or lines available
Original:  J:179427 Rajadhyaksha AM, et al., Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behav Brain Res. 2012 Jan 15;226(2):428-34
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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