About   Help   FAQ
Crbntm1.1Jjh
Targeted Allele Detail
Nomenclature
Symbol: Crbntm1.1Jjh
Name: cereblon; targeted mutation 1.1, Joseph Higgins
MGI ID: MGI:5302187
Gene: Crbn  Location: Chr6:106780201-106800077 bp, - strand  Genetic Position: Chr6, 49.24 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179427
Parent Cell Line:  CY2.4 (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector containing a FRT site flanked PGK-Neo selection cassette and a loxP site was utilized in the construction of this mutant. This selection cassette was inserted 227 bp upstream of exon 3 of the targeted gene, and another loxP site was inserted 225 bp downstream of exon 4. Flp-mediated recombination removed the neo cassette and left exons 3 and 4 floxed. (J:179427)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Crbn Mutation:  22 strains or lines available
References
Original:  J:179427 Rajadhyaksha AM, et al., Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability. Behav Brain Res. 2012 Jan 15;226(2):428-34
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/07/2017
MGI 6.11
The Jackson Laboratory