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Lmnb2tm1Yxz
Targeted Allele Detail
Nomenclature
Symbol: Lmnb2tm1Yxz
Name: lamin B2; targeted mutation 1, Yixian Zheng
MGI ID: MGI:5301971
Gene: Lmnb2  Location: Chr10:80901203-80918245 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178993
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 1.54-kb proximal promoter region and first exon were replaced by a loxP-flanked neomycin resistance cassette via homologous recombination. (J:178993)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmnb2 Mutation:  13 strains or lines available
References
Original:  J:178993 Kim Y, et al., Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science. 2011 Dec 23;334(6063):1706-10
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory