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Cdkal1tm1.1Tomik
Targeted Allele Detail
Nomenclature
Symbol: Cdkal1tm1.1Tomik
Name: CDK5 regulatory subunit associated protein 1-like 1; targeted mutation 1.1, Kazuhito Tomizawa
MGI ID: MGI:5301441
Synonyms: Cdkal1flox
Gene: Cdkal1  Location: Chr13:29191746-29855674 bp, - strand  Genetic Position: Chr13, 12.93 cM, cytoband A3.3
Endoplasmic reticulum distention in Cdkal1tm1.2Tomik/Cdkal1tm1.2Tomik Tg(Ins2-cre)25Mgn/0 beta cells

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178248
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exon 5 floxed. (J:178248)
Generation of the Cdkal1tm1.1Tomik and Cdkal1tm1.2Tomik alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkal1 Mutation:  46 strains or lines available
References
Original:  J:178248 Wei FY, et al., Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest. 2011 Sep 1;121(9):3598-608
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory