Tg(Slco1c1-icre/ERT2)1Mrks
Transgene Detail

Summary

• Symbol: Tg(Slco1c1-icre/ERT2)1Mrks
• Name: transgene insertion 1, Markus Schwaninger
• MGI ID: MGI:5301361
• Synonyms: Slco1c1-CreER^T2
• Transgene: Tg(Slco1c1-icre/ERT2)1Mrks Location: unknown
• Alliance: Tg(Slco1c1-icre/ERT2)1Mrks page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Slco1c1-icre/ERT2)1Mrks expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slco1c1 (MGI:1889679)

• Mutation details: A bacterial artificial chromosome (BAC; RP24-85B20) was modified by homologous recombination to insert a codon-improved cre (icre) fused to a mutated human estrogen receptor ligand-binding domain (ERT2). The targeting construct, which also contained an Frt-flanked ampicillin resistance cassette, was electroporated into bacterial cells containing the BAC. Cells with recombinant BAC clones were induced with L-arabinose to induce Flp recombinase expression to excise the resistance marker. The BAC was isolated, purified and injected into mouse pronuclei to obtain transgenic animals. No founder information was available so line 1 was entered. (J:179050)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slco1c1 (mouse) Summary of all recombinase alleles driven by Slco1c1. Comparative matrix view of recombinase activities Alliance mouse Slco1c1 gene page

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:179050 Ridder DA, et al., TAK1 in brain endothelial cells mediates fever and lethargy. J Exp Med. 2011 Dec 19;208(13):2615-23
• All: 30 reference(s)