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Mecomtm1Aspe
Targeted Allele Detail
Summary
Symbol: Mecomtm1Aspe
Name: MDS1 and EVI1 complex locus; targeted mutation 1, Archibald Perkins
MGI ID: MGI:5301305
Synonyms: Mds1-Evi1tm1ap, MEm1
Gene: Mecom  Location: Chr3:30005445-30563937 bp, - strand  Genetic Position: Chr3, 12.66 cM
Alliance: Mecomtm1Aspe page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178429
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ/neo cassette was inserted downstream of the translation initiation site. RNA analysis of adult tissues showed that MDS1-EVI1 (ME) transcripts are undetectable in all tissues except for a very low level in kidney, whereas levels of Evi1 mRNAs are normal. (J:178429)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 29 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mecom Mutation:  52 strains or lines available
References
Original:  J:178429 Zhang Y, et al., PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood. 2011 Oct 6;118(14):3853-61
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory