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Nos1tm1(cre)Mgmj
Targeted Allele Detail
Nomenclature
Symbol: Nos1tm1(cre)Mgmj
Name: nitric oxide synthase 1, neuronal; targeted mutation 1, Martin G Myers, Jr
MGI ID: MGI:5301174
Synonyms: Nos1cre, Nos1-ires-cre
Gene: Nos1  Location: Chr5:118004904-118096905 bp, + strand  Genetic Position: Chr5, 57.29 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:179120
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsAn IRES-cre-Frt-neo-Frt cassette was inserted after the stop codon of the final 3' exon of the Nos1 gene by homologous recombination in R1 ES cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were crossed to C57BL/6J mice, and then backcrossed to C57BL/6J for 9 generations. (J:179120, J:183754)
Recombinase
activity
Activity:
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Driver: Nos1     Summary of all recombinase alleles driven by Nos1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nos1 Mutation:  50 strains or lines available
References
Original:  J:179120 Myers MG Jr, Generation of a Nos1-cre knockin allele. MGI Direct Data Submission. 2012;
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory