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Nkx3-2tm4.1(cre)Tlu
Targeted Allele Detail
Summary
Symbol: Nkx3-2tm4.1(cre)Tlu
Name: NK3 homeobox 2; targeted mutation 4.1, Thomas Lufkin
MGI ID: MGI:5300901
Synonyms: Bapx1FCFE
Gene: Nkx3-2  Location: Chr5:41918826-41921563 bp, - strand  Genetic Position: Chr5, 22.58 cM
Alliance: Nkx3-2tm4.1(cre)Tlu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178893
Parent Cell Line:  v6.4 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Nkx3-2tm4.1(cre)Tlu expression driven by 1 gene
 
Mutation detailsA targeting vector was generated by inserting an F2A-cre-F2A-EGFP-Frt-PGK-gb2-Neo-Frt cassette immediately before the stop codon of of the Nkx3-2 gene sequence in a BAC (RP24-148P5). The 19.6 kb BAC targeting vector was electroporated into V6.4 ES cells for homologous recombination. The neo cassette was subsequently removed by FLPe-mediated recombination. (J:178893)
Recombinase
activity
Activity:
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Driver: Nkx3-2 (mouse)
Summary of all recombinase alleles driven by Nkx3-2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 7 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx3-2 Mutation:  21 strains or lines available
References
Original:  J:178893 Sivakamasundari V, et al., New Bapx1(Cre-EGFP) mouse lines for lineage tracing and conditional knockout studies. Genesis. 2012 Apr;50(4):375-83
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory