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Ptpmt1tm2.1Ckq
Targeted Allele Detail
Nomenclature
Symbol: Ptpmt1tm2.1Ckq
Name: protein tyrosine phosphatase, mitochondrial 1; targeted mutation 2.1, Cheng-Kui Qu
MGI ID: MGI:5300822
Synonyms: PTPMT1fl, Ptpmt1flox
Gene: Ptpmt1  Location: Chr2:90910713-90918050 bp, - strand  Genetic Position: Chr2, 50.44 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178313
Parent Cell Line:  D1 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 1 through 3 floxed. (J:178313, J:194929)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpmt1 Mutation:  6 strains or lines available
References
Original:  J:178313 Shen J, et al., A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol. 2011 Dec;31(24):4902-16
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory