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Kitltm1.1Sjm
Targeted Allele Detail
Nomenclature
Symbol: Kitltm1.1Sjm
Name: kit ligand; targeted mutation 1.1, Sean J Morrison
MGI ID: MGI:5300819
Synonyms: Scfgfp
Gene: Kitl  Location: Chr10:100015630-100100416 bp, + strand  Genetic Position: Chr10, 51.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180431
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exon 2 with EGFP (in frame) and an FRT-flanked neomycin resistance cassette. The neomycin resistance cassette was removed by flp-mediated recombination. qRT-PCR confirmed the absence of transcript expression in the liver. (J:180431)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kitl Mutation:  30 strains or lines available
References
Original:  J:180431 Ding L, et al., Endothelial and perivascular cells maintain haematopoietic stem cells. Nature. 2012 Jan 26;481(7382):457-62
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory