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Hopxtm2.1(cre/ERT2)Joe
Targeted Allele Detail
Nomenclature
Symbol: Hopxtm2.1(cre/ERT2)Joe
Name: HOP homeobox; targeted mutation 2.1, Jonathan A Epstein
MGI ID: MGI:5300731
Synonyms: HopxERCre
Gene: Hopx  Location: Chr5:77086988-77115121 bp, - strand  Genetic Position: Chr5, 41.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178296
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsAn IRES-cre/ERT-Frt-PGK-neo-Frt cassette was inserted into the 3' UTR of the Hopx locus by homologous recombination in ES cells. Subsequently, these animals were crossed to mice expressing the Tg(ACTFLPe)9205Dym recombinase allele to remove the PGK-neo cassette. (J:178296)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Hopx     Summary of all recombinase alleles driven by Hopx.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hopx Mutation:  6 strains or lines available
References
Original:  J:178296 Takeda N, et al., Interconversion between intestinal stem cell populations in distinct niches. Science. 2011 Dec 9;334(6061):1420-4
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/13/2021
MGI 6.16
The Jackson Laboratory