Tg(Alb-F8*R593C)T4Mcal
Transgene Detail

Summary

• Symbol: Tg(Alb-F8*R593C)T4Mcal
• Name: transgene insertion T4, Michele Calos
• MGI ID: MGI:5300683
• Synonyms: huFVIII-R593C
• Transgene: Tg(Alb-F8*R593C)T4Mcal Location: unknown
• Alliance: Tg(Alb-F8*R593C)T4Mcal page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-F8*R593C)T4Mcal expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  F8 (2157)

  F8	(MGI:88383)

• Mutation details: The transgene was designed with the murine albumin (Alb) promoter driving expression of human coagulation factor VIII (F8) cDNA. This transgene contains an Arginine to Cysteine missense mutation at amino acid 612 (originally stated as 593), which is prevalent in patients with Hemophilia A. (J:178969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:178969 Bril WS, et al., Tolerance to factor VIII in a transgenic mouse expressing human factor VIII cDNA carrying an Arg(593) to Cys substitution. Thromb Haemost. 2006 Feb;95(2):341-7
• All: 2 reference(s)