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Skor2Tn(sb-Tyr)1799B.CA7BOve
Transposon induced Allele Detail
Nomenclature
Symbol: Skor2Tn(sb-Tyr)1799B.CA7BOve
Name: SKI family transcriptional corepressor 2; transposon insertion 1799B.CA7B, Paul A Overbeek
MGI ID: MGI:5300201
Synonyms: OVE1799B-CA7B
Gene: Skor2  Location: Chr18:76944100-76988037 bp, + strand  Genetic Position: Chr18, 51.93 cM
Mutation
origin
Strain of Origin:  FVB/N
Mutation
description
Allele Type:    Transposon induced
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMobilization of TgTn(sb-Tyr)1799BOve with Sleeping Beauty transposase from Tg(CAG-sb10)1Dla results in the integration of the transposon in a non-coding region 237 kbp upstream from the start codon of Skor2 [NCB137/mm9; 76,860,053] through intron 8 of Skor2 [NCB137/mm9; 77,133,014] deleting exons 1 through 8. Real-time RT-PCR confirmed the absence of transcript expression in the P0 cerebellum. (J:178818)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Skor2 Mutation:  24 strains or lines available
References
Original:  J:178818 Wang B, et al., Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development. 2011 Oct;138(20):4487-97
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory