Phb2^tm2.1Katz
Targeted Allele Detail

Summary

• Symbol: Phb2^tm2.1Katz
• Name: prohibitin 2; targeted mutation 2.1, Benita S Katzenellenbogen
• MGI ID: MGI:5299189
• Synonyms: REA^f, REA^flox
• Gene: Phb2 Location: Chr6:124689299-124693913 bp, + strand Genetic Position: Chr6, 59.17 cM
• Alliance: Phb2^tm2.1Katz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178347
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 6. An additional loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the neo cassette and left exons 2 through 6 floxed. (J:178347)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phb2 Mutation: 22 strains or lines available

References

• Original: J:178347 Park S, et al., Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice. Endocrinology. 2011 Nov;152(11):4336-49
• All: 3 reference(s)