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Phb2tm2.1Katz
Targeted Allele Detail
Nomenclature
Symbol: Phb2tm2.1Katz
Name: prohibitin 2; targeted mutation 2.1, Benita S Katzenellenbogen
MGI ID: MGI:5299189
Synonyms: REAf, REAflox
Gene: Phb2  Location: Chr6:124712336-124716950 bp, + strand  Genetic Position: Chr6, 59.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:178347
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 6. An additional loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the neo cassette and left exons 2 through 6 floxed. (J:178347)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phb2 Mutation:  5 strains or lines available
References
Original:  J:178347 Park S, et al., Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice. Endocrinology. 2011 Nov;152(11):4336-49
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory