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Targeted Allele Detail
Symbol: Pitx2tm1.1Sac
Name: paired-like homeodomain transcription factor 2; targeted mutation 1.1, Sally A Camper
MGI ID: MGI:5298075
Synonyms: Pitx2flox
Gene: Pitx2  Location: Chr3:129199878-129219591 bp, + strand  Genetic Position: Chr3, 57.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:104125
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsGene targeting was performed with a vector engineered to contain a loxP site downstream from exon 4 and a floxed neomycin cassette upstream of exon 4. The floxed neo cassette was excised by transient cre expression leaving exon 4 flanked by loxP sites. (J:51160)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:  11 strains or lines available
Original:  J:51160 Gage PJ, et al., Dosage requirement of Pitx2 for development of multiple organs. Development. 1999 Oct;126(20):4643-51
All:  23 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory