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Tg(Ggt1-Hif1a*)43Log
Transgene Detail
Summary
Symbol: Tg(Ggt1-Hif1a*)43Log
Name: transgene insertion 43, Lorraine J Gudas
MGI ID: MGI:5298013
Synonyms: gamma-HIF1alpha-M3, gamma-HIF1alpha-M3-43
Transgene: Tg(Ggt1-Hif1a*)43Log  Location: unknown  
Alliance: Tg(Ggt1-Hif1a*)43Log page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ggt1-Hif1a*)43Log expresses 1 gene
 
Mutation detailsThe rat promoter drives kidney proximal tubule-specific expression of the human cDNA with three amino acid substitutions (P402A, P564A, and N803A). Four lines were generated (8, 25, 32, and 43) with similar phenotypes. Line 43 exhibits the strongest phenotype. (J:177381)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:177381 Fu L, et al., Generation of a Mouse Model of Von Hippel-Lindau Kidney Disease Leading to Renal Cancers by Expression of a Constitutively Active Mutant of HIF1alpha. Cancer Res. 2011 Nov 1;71(21):6848-56
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory