About   Help   FAQ
Tg(Alb-F8)EBmre
Transgene Detail
Nomenclature
Symbol: Tg(Alb-F8)EBmre
Name: transgene insertion E, Birgit M Reipert
MGI ID: MGI:5297954
Transgene: Tg(Alb-F8)EBmre  Location: unknown  Genetic Position: Chr3, Syntenic
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Alb-F8)EBmre expresses 1 gene
 
Mutation detailsThe promoter drives liver-specific expression of the human cDNA with a poly A signal derived from the human growth hormone and alpha-fetoprotein enhancer elements. Lines E (one insertion on chromosome 3H3) and G (one insertion on chromosome XA6) were generated. Line E does not elicite an antibody response while line G elicites the highest level of antibody response. Protein expression is detected in various organs but not in the circulation. (J:176909)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:176909 van Helden PM, et al., Maintenance and break of immune tolerance against human factor VIII in a new transgenic hemophilic mouse model. Blood. 2011 Sep 29;118(13):3698-707
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/20/2015
MGI 5.21
The Jackson Laboratory