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Transgene Detail
Symbol: Tg(Alb-F8)EBmre
Name: transgene insertion E, Birgit M Reipert
MGI ID: MGI:5297954
Transgene: Tg(Alb-F8)EBmre  Location: unknown  Genetic Position: Chr3, Syntenic
Strain of Origin:  Not Specified
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Alb-F8)EBmre expresses 1 gene
Mutation detailsThe promoter drives liver-specific expression of the human cDNA with a poly A signal derived from the human growth hormone and alpha-fetoprotein enhancer elements. Lines E (one insertion on chromosome 3H3) and G (one insertion on chromosome XA6) were generated. Line E does not elicite an antibody response while line G elicites the highest level of antibody response. Protein expression is detected in various organs but not in the circulation. (J:176909)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:176909 van Helden PM, et al., Maintenance and break of immune tolerance against human factor VIII in a new transgenic hemophilic mouse model. Blood. 2011 Sep 29;118(13):3698-707
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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