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Lrrc7tm1.1Mabk
Targeted Allele Detail
Nomenclature
Symbol: Lrrc7tm1.1Mabk
Name: leucine rich repeat containing 7; targeted mutation 1.1, Mary B Kennedy
MGI ID: MGI:5297824
Gene: Lrrc7  Location: Chr3:158082891-158562221 bp, - strand  Genetic Position: Chr3, 81.68 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177836
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 3. A floxed hygro cassette was inserted downstream of exon 3. Cre-mediated recombination removed the hygro cassette and exon 3. The absence of protein expression was confirmed by western blot analysis on forebrain extracts. (J:177836)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrc7 Mutation:  56 strains or lines available
References
Original:  J:177836 Carlisle HJ, et al., Deletion of Densin-180 Results in Abnormal Behaviors Associated with Mental Illness and Reduces mGluR5 and DISC1 in the Postsynaptic Density Fraction. J Neurosci. 2011 Nov 9;31(45):16194-207
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory