Sirt2^tm1.1Cxd
Targeted Allele Detail

Summary

• Symbol: Sirt2^tm1.1Cxd
• Name: sirtuin 2; targeted mutation 1.1, Chu-Xia Deng
• MGI ID: MGI:5297582
• Synonyms: Sirt2(deltaE5-E8)
• Gene: Sirt2 Location: Chr7:28466192-28488086 bp, + strand Genetic Position: Chr7, 16.92 cM, cytoband B1-2
• Alliance: Sirt2^tm1.1Cxd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177486
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of exon 5. An addtional loxP site was inserted downstream of exon 8. Cre-mediated recombination removed exons 5 through 8 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on embryo extracts. (J:177486)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Sirt2^tm1.1Cxd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt2 Mutation: 25 strains or lines available

References

• Original: J:177486 Kim HS, et al., SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity. Cancer Cell. 2011 Oct 18;20(4):487-99
• All: 5 reference(s)