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Targeted Allele Detail
Symbol: Cd68tm1Xfen
Name: CD68 antigen; targeted mutation 1, Xu Feng
MGI ID: MGI:5297542
Gene: Cd68  Location: Chr11:69664213-69666153 bp, - strand  Genetic Position: Chr11, 42.86 cM
Cd68tm1Xfen/Cd68tm1Xfen mice have increased trabecular bone and decreased trabecular tissue mineral density

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:178120
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2 were replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on bone marrow-derived macrophage. (J:178120)
Generation of the Cd68tm1Xfen allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd68 Mutation:  26 strains or lines available
Original:  J:178120 Ashley JW, et al., Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts. PLoS One. 2011;6(10):e25838
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory