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Targeted Allele Detail
Symbol: Cd68tm1Xfen
Name: CD68 antigen; targeted mutation 1, Xu Feng
MGI ID: MGI:5297542
Gene: Cd68  Location: Chr11:69664213-69666153 bp, - strand  Genetic Position: Chr11, 42.86 cM
Cd68tm1Xfen/Cd68tm1Xfen mice have increased trabecular bone and decreased trabecular tissue mineral density

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:178120
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2 were replaced with a floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on bone marrow-derived macrophage. (J:178120)
Generation of the Cd68tm1Xfen allele
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd68 Mutation:  19 strains or lines available
Original:  J:178120 Ashley JW, et al., Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts. PLoS One. 2011;6(10):e25838
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
The Jackson Laboratory