Aqp4^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Aqp4^tm1.1Geno
• Name: aquaporin 4; targeted mutation 1.1, Genoway
• MGI ID: MGI:5297539
• Synonyms: Aqp4^flox
• Gene: Aqp4 Location: Chr18:15522553-15544039 bp, - strand Genetic Position: Chr18, 8.74 cM
• Alliance: Aqp4^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177412
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 1 through 3 floxed. (J:177412)

Generation of the conditional Aqp4^tm1.1Geno allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp4 Mutation: 42 strains or lines available

References

• Original: J:177412 Haj-Yasein NN, et al., Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17815-20
• All: 3 reference(s)