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Chemically induced Allele Detail
Symbol: Foxj1b2b774Clo
Name: forkhead box J1; Bench to Bassinet Program (B2B/CVDC), mutation 774 Cecilia Lo
MGI ID: MGI:5297425
Synonyms: Foxj1T425A, Tails
Gene: Foxj1  Location: Chr11:116221530-116226225 bp, - strand  Genetic Position: Chr11, 81.16 cM
Situs inversus totalis indicated by dextrocardia and dextrogastria

Show the 4 phenotype image(s) involving this allele.

Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
Mutation detailsThis ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is a T to A substitution at coding nucleotide 425 in exon 2 of the cDNA (c.425T>A, NM_008240). This changes the isoleucine residue to asparagine at position 142 in the encoding protein (p.I142N). (J:175213) Additional incidental mutations were detected in sequencing for the causative mutation, Foxj1b2b774Clo, and may be present in stocks carrying this mutation.
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Foxj1 Mutation:  10 strains or lines available
Summative Diagnosis:
Laterality defects: Situs inversus totalis and heterotaxy

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0100 Situs inversus totalis
3608 Left ventricular hypertrophy
3609 Right ventricular hypertrophy
3974 {I,L,I}

Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory