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b2b464Clo
Chemically induced Allele Detail
Nomenclature
Symbol: b2b464Clo
Name: Mutant line 464; Bench to Bassinet Program (B2B/CVDC), mutation 464 Cecilia Lo
MGI ID: MGI:5297424
Gene: b2b464Clo  Location: unknown  
Mutant 464-003-NA presents with hypoplastic left ventricle, and hypoplastic aorta as confirmed by EFIC imaging.

Show the 10 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  C57BL/6J
Project Collection: B2B/CvDC
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Undefined
    This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. Additional incidental mutations were detected in sequencing for the causative mutation, b2b464Clo, and may be present in stocks carrying this mutation.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any b2b464Clo Mutation:  2 strains or lines available
Notes
Summative Diagnosis:
Cardiovascular phenotype: Hypoplastic left ventricle (LV), aortic valve hypoplasia, hypoplastic aorta (Ao), hypoplastic mitral valve, aortic arch hypoplasia and atrial septal defect (ASD).

Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Code ID Code Description
0300 Hypoplastic left heart syndrome
1400 Aortic valve abnormality
1515 Hypoplastic mitral valve
1811 Hypoplastic left ventricle (subnormal cavity volume)
2050 Atrial septal defect
2704 Aortic arch hypoplasia

References
Original:  J:175213 Lo C, Information submitted by the NHLBI Cardiovascular Development Consortium (CvDC), Bench to Bassinet Program (B2B/CvDC). MGI Direct Data Submission (B2B/CvDC). 2011-15;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory