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Targeted Allele Detail
Symbol: Disc1tm1Kozo
Name: disrupted in schizophrenia 1; targeted mutation 1, Kozo Kaibuchi
MGI ID: MGI:5296951
Synonyms: Disc1delta2-3
Gene: Disc1  Location: Chr8:125780934-125988597 bp, + strand  Genetic Position: Chr8, 73.26 cM
Germline Transmission:  Earliest citation of germline transmission: J:177560
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
Mutation detailsMost of exon 2 and all of exon 3 were replaced with a stop codon and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:177560)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Disc1 Mutation:  49 strains or lines available
Original:  J:177560 Kuroda K, et al., Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet. 2011 Dec 1;20(23):4666-83
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory