About   Help   FAQ
Disc1tm1Kozo
Targeted Allele Detail
Nomenclature
Symbol: Disc1tm1Kozo
Name: disrupted in schizophrenia 1; targeted mutation 1, Kozo Kaibuchi
MGI ID: MGI:5296951
Synonyms: Disc1delta2-3
Gene: Disc1  Location: Chr8:125780934-125988597 bp, + strand  Genetic Position: Chr8, 73.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177560
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exon 2 and all of exon 3 were replaced with a stop codon and floxed neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:177560)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Disc1 Mutation:  49 strains or lines available
References
Original:  J:177560 Kuroda K, et al., Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse. Hum Mol Genet. 2011 Dec 1;20(23):4666-83
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2022
MGI 6.21
The Jackson Laboratory