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Targeted Allele Detail
Symbol: Itgb1tm11.1Ref
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 11.1, Reinhard Fassler
MGI ID: MGI:5296846
Synonyms: YY783/795FF, YY/FF
Gene: Itgb1  Location: Chr8:128685654-128733200 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:177979
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA floxed neo cassette was inserted downstream of a modified exon 16 in which nucleotide substitutions result in the amino acid substitution of phenylalanine for tyrosine at positions 783 and 795 (Y783F and Y795). Cre-mediated recombination removed the neo cassette. (J:177979)
Targeting strategy for introducing point mutations in the cytoplasmic domain of Itgb1
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  13 strains or lines available
Original:  J:177979 Czuchra A, et al., Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol. 2006 Sep 11;174(6):889-99
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory