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Itgb1tm11.1Ref
Targeted Allele Detail
Nomenclature
Symbol: Itgb1tm11.1Ref
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 11.1, Reinhard Fassler
MGI ID: MGI:5296846
Synonyms: YY783/795FF, YY/FF
Gene: Itgb1  Location: Chr8:128685654-128733200 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177979
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA floxed neo cassette was inserted downstream of a modified exon 16 in which nucleotide substitutions result in the amino acid substitution of phenylalanine for tyrosine at positions 783 and 795 (Y783F and Y795). Cre-mediated recombination removed the neo cassette. (J:177979)
Targeting strategy for introducing point mutations in the cytoplasmic domain of Itgb1
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  13 strains or lines available
References
Original:  J:177979 Czuchra A, et al., Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol. 2006 Sep 11;174(6):889-99
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory