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Itgb1tm10.1Ref
Targeted Allele Detail
Summary
Symbol: Itgb1tm10.1Ref
Name: integrin beta 1 (fibronectin receptor beta); targeted mutation 10.1, Reinhard Fassler
MGI ID: MGI:5296845
Synonyms: Y795F
Gene: Itgb1  Location: Chr8:129412135-129459681 bp, + strand  Genetic Position: Chr8, 76.09 cM, cytoband E2
Alliance: Itgb1tm10.1Ref page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177979
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Not Specified)
Mutations:    Insertion, Single point mutation
 
Mutation detailsA floxed neo cassette was inserted downstream of a modified exon 16 in which nucleotide substitution results in the amino acid substitution of phenylalanine for tyrosine at position 795 (Y795F). Cre-mediated recombination removed the neo cassette. (J:177979)
Targeting strategy for introducing point mutations in the cytoplasmic domain of Itgb1
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb1 Mutation:  59 strains or lines available
References
Original:  J:177979 Czuchra A, et al., Genetic analysis of beta1 integrin "activation motifs" in mice. J Cell Biol. 2006 Sep 11;174(6):889-99
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory