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Cttntm1.2Dvst
Targeted Allele Detail
Nomenclature
Symbol: Cttntm1.2Dvst
Name: cortactin; targeted mutation 1.2, Dietmar Vestweber
MGI ID: MGI:5296621
Synonyms: Cttndel
Gene: Cttn  Location: Chr7:144435733-144471009 bp, - strand  Genetic Position: Chr7, 88.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177602
Parent Cell Line:  IDG3.2 (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exon 7. The absence of protein expression was confirmed by immunoblotting. (J:177602)
Generation of the Cttntm1.1Dvst and Cttntm1.2Dvst alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cttn Mutation:  20 strains or lines available
References
Original:  J:177602 Schnoor M, et al., Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J Exp Med. 2011 Aug 1;208(8):1721-35
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory