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Col1a1tm1(CAG-Sirt2)Jmi
Targeted Allele Detail
Summary
Symbol: Col1a1tm1(CAG-Sirt2)Jmi
Name: collagen, type I, alpha 1; targeted mutation 1, Jeffrey Milbrandt
MGI ID: MGI:5295482
Synonyms: Sirt2STOP
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm1(CAG-Sirt2)Jmi page
Delayed remyelination after nerve crush injury in Col1a1tm1(CAG-Sirt2)Jmi/Col1a1tm1(CAG-Sirt2)Jmi Tg(Mpz-cre)26Mes/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177468
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Col1a1tm1(CAG-Sirt2)Jmi expresses 1 gene
 
Mutation detailsThe SIRT2-Tg flox-STOP-flox construct was designed to insert (from 5' to 3') an FRT site, a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG; from the pCAGGS vector), a loxP-flanked transcriptional STOP cassette, the mouse sirtuin 2 (Sirt2) cDNA sequence, and a PGK-hygro-polyA sequence (with a second FRT site between the PGK and hygro) into the 3' UTR of the mouse collagen A1 (Col1a1) locus. (J:177468)
Generation of the Col1a1tm1(CAG-Sirt2)Jmi allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  160 strains or lines available
References
Original:  J:177468 Beirowski B, et al., Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E952-61
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory