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Targeted Allele Detail
Symbol: Hcn2tm1.2Lex
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 2; targeted mutation 1.2, Lexicon Genetics
MGI ID: MGI:5295435
Gene: Hcn2  Location: Chr10:79716634-79736108 bp, + strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Germline Transmission:  Earliest citation of germline transmission: J:176663
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Project Collection: Lexicon
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsCre-mediated recombination removed exons 2 and 3. The absence of protein expression was confirmed by western blot analysis on brain, spinal cord, and dorsal root ganglia. (J:176663)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcn2 Mutation:  2 strains or lines available
Original:  J:176663 Emery EC, et al., HCN2 ion channels play a central role in inflammatory and neuropathic pain. Science. 2011 Sep 9;333(6048):1462-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory