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Lrrk2tm1.2Npa
Targeted Allele Detail
Nomenclature
Symbol: Lrrk2tm1.2Npa
Name: leucine-rich repeat kinase 2; targeted mutation 1.2, Novartis Pharma AG
MGI ID: MGI:5295370
Gene: Lrrk2  Location: Chr15:91673175-91816120 bp, + strand  Genetic Position: Chr15, 46.07 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:176679
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Cre mediated recombination removed the modified exon 41. (J:176679)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrrk2 Mutation:  28 strains or lines available
References
Original:  J:176679 Herzig MC, et al., LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. Hum Mol Genet. 2011 Nov 1;20(21):4209-23
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory