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Muc5actm1.1Evns
Targeted Allele Detail
Nomenclature
Symbol: Muc5actm1.1Evns
Name: mucin 5, subtypes A and C, tracheobronchial/gastric; targeted mutation 1.1, Christopher M Evans
MGI ID: MGI:5295259
Synonyms: Muc5acdelta, Muc5actm1.1Tigm
Gene: Muc5ac  Location: Chr7:141788972-141819231 bp, + strand  Genetic Position: Chr7, 87.23 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177306
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed the floxed exon 1. The absence of protein expression was confirmed by immunofluorescence on cecum samples. (J:177306)
Generation of the Muc5actm1.1Evns allele
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Muc5ac Mutation:  46 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Dry Eye Syndrome J:195649
References
Original:  J:177306 Hasnain SZ, et al., Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011 May 9;208(5):893-900
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory