Tg(Thy1-BSCL2*N88S)1Dit
Transgene Detail

Summary

• Symbol: Tg(Thy1-BSCL2*N88S)1Dit
• Name: transgene insertion 1, Daisuke Ito
• MGI ID: MGI:5295199
• Synonyms: N88S tg
• Transgene: Tg(Thy1-BSCL2*N88S)1Dit Location: unknown
• Alliance: Tg(Thy1-BSCL2*N88S)1Dit page

Transgene origin

• Strain of Origin: (C57BL/6NCrSlc x DBA/2CrSlc)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-BSCL2*N88S)1Dit expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BSCL2 (26580)

  Bscl2

  (MGI:1298392)

  Transgene codes for a protein with an arginine to serine mutation.

• Mutation details: This transgene consists of the human seipin (BSCL2) cDNA with the N88S mutation tagged with Myc and V5-His under the control of the mouse Thy1 promoter. (J:175537)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:175537 Yagi T, et al., N88S seipin mutant transgenic mice develop features of seipinopathy/BSCL2-related motor neuron disease via endoplasmic reticulum stress. Hum Mol Genet. 2011 Oct 1;20(19):3831-40
• All: 2 reference(s)