Zeb1^tm1.1Ajg
Targeted Allele Detail

Summary

• Symbol: Zeb1^tm1.1Ajg
• Name: zinc finger E-box binding homeobox 1; targeted mutation 1.1, Andrew J Griffith
• MGI ID: MGI:5295192
• Synonyms: KI^A
• Gene: Zeb1 Location: Chr18:5591860-5775467 bp, + strand Genetic Position: Chr18, 4.42 cM
• Alliance: Zeb1^tm1.1Ajg page

Ear abnormalities in Zeb1^tm2.1Ajg/Zeb1^tm1.1Ajg and Zeb1^tm1.1Ajg/Zeb1^tm1.1Ajg mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:177274
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Single point mutation Mutation details: A single nucleotide G to A substitution located 181 bp downstream of Zeb1 exon 1 and 12 bp downstream of exon 1 of the predicted gene Gm10125, a loxP site, and IRES-lacZ cassette, and a floxed inverted pgk-neo cassette were inserted via homologous recombination. Cre mediated recombination removed the IRES-lacZ and pgk-neo cassettes. This mutation is designed to duplicate the one found in Zeb1^Tw mice (J:177274)

Generation of the Zeb1^tm2.1Ajg and Zeb1^tm1.1Ajg alleles

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zeb1 Mutation: 65 strains or lines available

References

• Original: J:177274 Kurima K, et al., A noncoding point mutation of zeb1 causes multiple developmental malformations and obesity in twirler mice. PLoS Genet. 2011 Sep;7(9):e1002307
• All: 1 reference(s)