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Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pion)Pggd
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(H1/tetO-RNAi:Pion)Pggd
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Paul Greengard
MGI ID: MGI:5294908
Synonyms: GSAP-RNAi
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077333 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:163997
Parent Cell Line:  ART4.12 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Inducible, Knockdown, RMCE-ready)
Mutation:    Insertion
 
Mutation detailsThe short hairpin RNA (shRNA) against Pion (5'-TCCCGGAACTCCATGATTGACAAATTTCAAGAGAATTTGTCAATCATGGAGTTCCTTTTTA-3') was inserted into the locus via RMCE with Gt(ROSA)26Sortm1(CAG-flpe)Arte. The shRNA sequence is under the regulation of the tetO operator and a codon optimized tet repressor (itetR) under the control of a CAG promoter. (J:163997)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  253 strains or lines available
References
Original:  J:163997 He G, et al., Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature. 2010 Sep 2;467(7311):95-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory