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Targeted Allele Detail
Symbol: Hsp90aa1tm1.1Udon
Name: heat shock protein 90, alpha (cytosolic), class A member 1; targeted mutation 1.1, Heiichiro Udono
MGI ID: MGI:5294812
Gene: Hsp90aa1  Location: Chr12:110690605-110702728 bp, - strand  Genetic Position: Chr12, 60.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:177143
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neo cassette was inserted upstream of exon 9. An additional loxP site was inserted downstream of exon 10. Cre-mediated recombination removed the neo cassette and exons 9 and 10. The absence of protein expression was confirmed by western blot analysis on liver, kidney, lung, brain, tesis, and bone marrow-derived dendritic cells. (J:177143)
Generation of the Hsp90aa1tm1.1Udon allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsp90aa1 Mutation:  27 strains or lines available
Original:  J:177143 Imai T, et al., Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16363-8
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory