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Hsp90aa1tm1.1Udon
Targeted Allele Detail
Nomenclature
Symbol: Hsp90aa1tm1.1Udon
Name: heat shock protein 90, alpha (cytosolic), class A member 1; targeted mutation 1.1, Heiichiro Udono
MGI ID: MGI:5294812
Gene: Hsp90aa1  Location: Chr12:110690605-110702728 bp, - strand  Genetic Position: Chr12, 60.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177143
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 9. An additional loxP site was inserted downstream of exon 10. Cre-mediated recombination removed the neo cassette and exons 9 and 10. The absence of protein expression was confirmed by western blot analysis on liver, kidney, lung, brain, tesis, and bone marrow-derived dendritic cells. (J:177143)
Generation of the Hsp90aa1tm1.1Udon allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsp90aa1 Mutation:  27 strains or lines available
References
Original:  J:177143 Imai T, et al., Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16363-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory