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Pmeltm1.1Sson
Targeted Allele Detail
Summary
Symbol: Pmeltm1.1Sson
Name: premelanosome protein; targeted mutation 1.1, Leif Andersson
MGI ID: MGI:5294792
Synonyms: Pmel-
Gene: Pmel  Location: Chr10:128540064-128556107 bp, + strand  Genetic Position: Chr10, 77.13 cM
Alliance: Pmeltm1.1Sson page
Altered shape of melanosomes in Pmeltm1.1Sson/Pmeltm1.1Sson skin

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177116
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were floxed and an FRT flanked neo cassette was inserted downstream of exon 3 via homologous recombination. Exons 2 and 3 were deleted by cre mediated recombination. (J:177116)
Strategy for the generation of the Pmeltm1Sson and Pmeltm1.1Sson alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pmel Mutation:  36 strains or lines available
References
Original:  J:177116 Hellstrom AR, et al., Inactivation of pmel alters melanosome shape but has only a subtle effect on visible pigmentation. PLoS Genet. 2011 Sep;7(9):e1002285
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory