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Gstk1tm1Pgb
Targeted Allele Detail
Nomenclature
Symbol: Gstk1tm1Pgb
Name: glutathione S-transferase kappa 1; targeted mutation 1, Philip G Board
MGI ID: MGI:5294676
Gene: Gstk1  Location: Chr6:42245935-42250441 bp, + strand  Genetic Position: Chr6, 20.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:177201
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neo cassette replaced exons 4 and 5. The absence of protein expression was confirmed by western blot analysis on liver, kidney, and heart extracts. (J:177201)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gstk1 Mutation:  3 strains or lines available
References
Original:  J:177201 Blackburn AC, et al., Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress. Lab Invest. 2011 Nov;91(11):1572-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory