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Map3k12tm1Lewc
Targeted Allele Detail
Summary
Symbol: Map3k12tm1Lewc
Name: mitogen-activated protein kinase kinase kinase 12; targeted mutation 1, Joseph W Lewcock
MGI ID: MGI:5294467
Synonyms: DLKfl, DLKlox
Gene: Map3k12  Location: Chr15:102406079-102425311 bp, - strand  Genetic Position: Chr15, 57.63 cM, cytoband F3
Alliance: Map3k12tm1Lewc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:196076
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 5. (J:176956)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k12 Mutation:  39 strains or lines available
References
Original:  J:176956 Ghosh AS, et al., DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. J Cell Biol. 2011 Sep 5;194(5):751-64
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory