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Targeted Allele Detail
Symbol: Cdkn1ctm2.1Kei
Name: cyclin-dependent kinase inhibitor 1C (P57); targeted mutation 2.1, Keiichi I Nakayama
MGI ID: MGI:5294426
Synonyms: p57Flox
Gene: Cdkn1c  Location: Chr7:143458350-143461050 bp, - strand  Genetic Position: Chr7, 88.22 cM
Germline Transmission:  Earliest citation of germline transmission: J:176209
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted upstream of exon 2. A floxed neo cassette was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette and left exons 2 through 4 floxed. (J:176209)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1c Mutation:  7 strains or lines available
Original:  J:176209 Matsumoto A, et al., p57 Is Required for Quiescence and Maintenance of Adult Hematopoietic Stem Cells. Cell Stem Cell. 2011 Sep 2;9(3):262-71
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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