Cacna1c^tm5.1Hfm
Targeted Allele Detail

Summary

• Symbol: Cacna1c^tm5.1Hfm
• Name: calcium channel, voltage-dependent, L type, alpha 1C subunit; targeted mutation 5.1, Franz Hofmann
• MGI ID: MGI:5293799
• Synonyms: CaV1.2^D1904stop
• Gene: Cacna1c Location: Chr6:118564201-119173851 bp, - strand Genetic Position: Chr6, 55.86 cM
• Alliance: Cacna1c^tm5.1Hfm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176723
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Single point mutation Mutation details: Exon 44 was replaced with one in which nucleotide substitution results in the amino acid substitution of a stop codon for aspartic acid at position 1904 (D1904Stop) and a floxed neo cassette. Cre-mediated recombination removed the neo cassette. (J:176723)

Generation of the Cacna1c^tm5.1Hfm allele

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacna1c Mutation: 141 strains or lines available

References

• Original: J:176723 Domes K, et al., Truncation of murine cav1.2 at asp-1904 results in heart failure after birth. J Biol Chem. 2011 Sep 30;286(39):33863-71
• All: 2 reference(s)