Hcn1^tm1.1Lex
Targeted Allele Detail

Summary

• Symbol: Hcn1^tm1.1Lex
• Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1; targeted mutation 1.1, Lexicon Genetics
• MGI ID: MGI:5293229
• Gene: Hcn1 Location: Chr13:117738856-118117564 bp, + strand Genetic Position: Chr13, 66.34 cM
• Alliance: Hcn1^tm1.1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176560
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exon 1 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain and spleen extracts. (J:176560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hcn1 Mutation: 49 strains or lines available

References

• Original: J:176560 Momin A, et al., Role of the hyperpolarization-activated current Ih in somatosensory neurons. J Physiol. 2008 Dec 15;586(Pt 24):5911-29
• All: 1 reference(s)