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Hcn1tm1.1Lex
Targeted Allele Detail
Nomenclature
Symbol: Hcn1tm1.1Lex
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 1; targeted mutation 1.1, Lexicon Genetics
MGI ID: MGI:5293229
Gene: Hcn1  Location: Chr13:117602320-117987418 bp, + strand  Genetic Position: Chr13, 66.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:176560
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Project Collection: Lexicon
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exon 1 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain and spleen extracts. (J:176560)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hcn1 Mutation:  21 strains or lines available
References
Original:  J:176560 Momin A, et al., Role of the hyperpolarization-activated current Ih in somatosensory neurons. J Physiol. 2008 Dec 15;586(Pt 24):5911-29
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory