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Targeted Allele Detail
Symbol: Apba3tm1.1Ski
Name: amyloid beta (A4) precursor protein-binding, family A, member 3; targeted mutation 1.1, Motoharu Seiki
MGI ID: MGI:5293146
Synonyms: Apba3fl
Gene: Apba3  Location: Chr10:81266960-81273246 bp, + strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:176742
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsAn FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 2 and 3 floxed. (J:176742)
Generation of the Apba3tm1.1Ski allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apba3 Mutation:  2 strains or lines available
Original:  J:176742 Hara T, et al., Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock. J Biol Chem. 2011 Sep 16;286(37):32542-51
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory