Apba3^tm1.1Ski
Targeted Allele Detail

Summary

• Symbol: Apba3^tm1.1Ski
• Name: amyloid beta precursor protein binding family A member 3; targeted mutation 1.1, Motoharu Seiki
• MGI ID: MGI:5293146
• Synonyms: Apba3^fl
• Gene: Apba3 Location: Chr10:81102799-81109081 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Apba3^tm1.1Ski page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:176742
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neo cassette and left exons 2 and 3 floxed. (J:176742)

Generation of the Apba3^tm1.1Ski allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apba3 Mutation: 22 strains or lines available

References

• Original: J:176742 Hara T, et al., Deletion of the Mint3/Apba3 gene in mice abrogates macrophage functions and increases resistance to lipopolysaccharide-induced septic shock. J Biol Chem. 2011 Sep 16;286(37):32542-51
• All: 2 reference(s)